2022
Codenotti S ;Zizioli D, ;Mignani L, ;Rezzola S;Tabellini G,;Parolini S;Giacomini A, Asperti M, ;Poli M, ;Mandracchia D, ;Vezzoli M, ;Bernardi S, Russo D, ;Mitola S, ;Monti E, ;Triggiani L, ;TomasiniD, ;Gastaldello S, Cassandri M, ;Rota R, ;Marampon F;Fanzani A. Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors. DOI10.3390/cells11182859.
Pike AF, Longhena F, Faustini G, van Eik JM, Gombert I, Herrebout MAC, Fayed MMHE, Sandre M, Varanita T, Teunissen CE, Hoozemans JJM, Bellucci A, Veerhuis R, Bubacco L. Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. J Neuroinflammation. DOI: 10.1186/s12974-022-02410-4.
Casiraghi A, Longhena F, Faustini G, Ribaudo G, Suigo L, Camacho-Hernandez GA, Bono F, Brembati V, Hauck Newman A, Gianoncelli A, Straniero V, Bellucci A, Valoti E. Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice DOI: 10.3390/pharmaceutics14081595.
Ponterio G, Faustini G, El-Atiallah I, Sciamanna G, Meringolo M, Tassone A, Imbriani P, Cerri S, Martella G, Bonsi P, Bellucci A*, Pisani A. Alpha-synuclein is involved in DYT1 dystonia striatal synaptic dysfunction. doi: 10.1002/mds.29024.
Faustini G, Longhena F, Masato A, Bassareo V, Frau R, Klingstedt T, Shirani H, Brembati V, Parrella E, Vezzoli M, Nilsson KPR, Pizzi M, Spillantini MG, Bubacco L, Bellucci A. Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype. Mol Ther. 2022, S1525-0016(22)00021-1. doi: 10.1016/j.ymthe.2022.01.021.
Faustini G, Longhena F, Muscò A, Bono F, Parrella E, La Via L, Barbon A, Pizzi M, Onofri F, Benfenati F, Missale C, Memo M, Zizioli D, Bellucci A. Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates. Cells. 2022, 11:3902. doi: 10.3390/cells11233902.
Sala N ;Paoli C;Bonifacino T;Mingardi J ;Schiavon E;La Via L;Milanese M;Tornese P;Datusalia A;Rosa J; Facchinetti R; Frumento, Carini G, Salerno S, Scuderi C; Forti L; Barbon A; Bonann G;Popoli M Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex. DOI: 10.3389/fphar.2022.759626
2021
Corsini M, Ravelli C, Grillo E, Dell'Era P, Presta M, Mitola S.Simultaneously characterization of tumoral angiogenesis and vasculogenesis in stem cell-derived teratomas.doi: 10.1016/j.yexcr.2021.112490
Mingardi J, La Via L.,Tornese P,Carini G,Trontti K, Seguini M,Tardito D, Bono F. Fiorentini C., Elia L,Hovatta I,Popoli M,Musazzi L, BarbonaA miR-9-5p is involved in the rescue of stress-dependent dendritic shortening of hippocampal pyramidal neurons induced by acute antidepressant treatment with ketamine.doi: 10.1016/j.ynstr.2021.100381
Filippini A, Mutti V, Faustini G, Longhena F, Ramazzina I, Rizzi F, Kaganovich A, Roosen DA, Landeck N, Duffy M, Tessari I, Bono F, Fiorentini C, Greggio E, Bubacco L, Bellucci A, Missale M, Cookson MR, Gennarelli M, Russo I. Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes. doi:10.1002/glia.23920
Scutera S, Mitola S, Sparti R, Salvi V, Grillo E, Piersigilli G, Bugatti M, Alotto D, Schioppa T, Sozzani S, Musso T. Bartonella henselae Persistence within Mesenchymal Stromal Cells Enhances Endothelial Cell Activation and Infectibility That Amplifies the Angiogenic Process.doi: 10.1128/IAI.00141-21.
Biagiotti G, Angeli A, Giacomini A, Toniolo G, Landini L, Salerno G, Di Cesare Mannelli L, Ghelardini C, MelloT, Mussi S, Ravelli C, Marelli M, Cicchi S, Menna E, Ronca R, Supuran C, Richichi B.Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells.doi: 10.1021/acsanm.1c03603
Ronca R, Taranto S, Corsini M, Tobia C, Ravelli C, Rezzola S, Belleri M, De Cillis F, Cattaneo A, Presta M, Giacomini A.Pentraxin 3 Inhibits the Angiogenic Potential of Multiple Myeloma Cells.doi: 10.3390/cancers13092255
Bugatti A, Caccuri F, Filippini F, Ravelli C, Caruso A.Binding to PI(4,5)P 2 is indispensable for secretion of B-cell clonogenic HIV-1 matrix protein p17 variants.DOI: 10.1016/j.jbc.2021.100934
Bono F, Mutti V, Devoto P, Bolognin S, Schwamborn JC, Missale C, Fiorentini C.
Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation.
doi:10.1016/j.neurobiolaging.2020.12.001
Bono F, Mutti V, Piovani G, Minelli A, Mingardi J, Guglielmi A, Missale C, Gennarelli M, Fiorentini C, Barbon A. Establishment and characterization of induced pluripotent stem cell (iPSCs) line UNIBSi014-A from a healthy female donor. doi:10.1016/j.scr.2021.102216. 1.
Sacco A, Federico C, Todoerti K, Ziccheddu B, Palermo V, Giacomini A, Ravelli C, Maccarinelli F, Bianchi G, Belotti A, Ribolla R, Favasuli V, Revenko AS, MacLeod RA, Willis BS, Cai H, Hauser J, Rooney C, Willis SE, Martin PL, Staniszewska AD, Ambrose H, Hanson L, Cattaneo C, Tucci A, Rossi G, Ronca R, Neri A, Mitola S, Bolli N, Presta M, Moschetta M, Ross S, Roccaro AM.Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited anti-tumor activity. doi: 10.1182/blood.2020010572.
2020
Faustini G, Longhena F, Bruno A, Bono F, Grigoletto J, La Via L, Barbon A, Casiraghi A, Straniero V, Valoti E, Costantino G, Benfenati F, Missale C, Pizzi M, Spillantini MG, Bellucci A. Alpha-synuclein/synapsin III Pathological Interplay Boosts the Motor Response to Methylphenidate. Neurobiology of disease. DOI: 10.1016/j.nbd.2020.104789.
Bono F, Mutti V, Devoto P, Bolognin S, Schwamborn JC, Missale C, Fiorentini C. Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson's disease patients carrying the LRRK2 G2019S mutation. Neurobiology of aging. doi: 10.1016/j.neurobiolaging.2020.12.001.
Ronca R, Ghedini GC, Maccarinelli F, Sacco A, Locatelli SL, Foglio E, Taranto S, Grillo E, Matarazzo S, Castelli R, Paganini G, Desantis V, Cattane N, Cattaneo A, Mor M, Carlo-Stella C, Belotti A, Roccaro A, Presta M, Giacomini A. FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress. Cancer Research. 10.1158/0008-5472.CAN-19-2714.
Casiraghi A, Longhena F, Straniero V, Faustini G, Newman AH, Bellucci A, Valoti E. Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET-Based Assay of Synapsin III Binding. ChemMedChem. 10.1002/cmdc.202000128.
Grillo E, Corsini M, Ravelli C, di Somma M, Zammataro L, Monti E, Presta M and Mitola S. A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis. Cancer letters. 10.1016/j.canlet.2020.09.027.
González-González A, González A, Rueda N, Alonso-González C, Menéndez JM, Martínez-Campa C, Mitola S, Cos S. Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process. Sci rep. 10.1038/s41598-020-61622-x.
Bono F, Mutti V, Piovani G, Minelli A, Mingardi J, Guglielmi A, Fiorentini C, Barbon A, Missale C, Gennarelli M. Generation of two human induced pluripotent stem cell lines, UNIBSi012-A and UNIBSi013-A, from two patients with treatment-resistant depression. Stem Cell Research. doi: 10.1016/j.scr.2020.102104.
2019
Amodeo R, Nifosì R, Giacomelli C, Ravelli C, La Rosa L, Callegari A, Trincavelli ML, Mitola S, Luin S, Marchetti L. Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants. BBAMCR. doi: 10.1016/j.bbamcr.2019.118614.
Rezzola S, Di Somma M, Corsini M, Leali D, Ravelli C, Polli VAB, Grillo E, Presta M, Mitola S. VEGFR2 activation mediates the pro-angiogenic activity of BMP4. Angiogenesis. doi: 10.1007/s10456-019-09676-y.
Tobia C, Chiodelli P, Barbieri A, Buraschi S, Ferrari E, Mitola S, Borsani G, Guerra J, Presta M. Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Front Immunol. doi: 10.3389/fimmu.2019.01092.
Parrella E, Bellucci A, Porrini V, Benarese M, Lanzillotta A, Faustini G, Longhena F, Abate G, Uberti D, Pizzi M. NF-κB/c-Rel deficiency causes Parkinson's disease-like prodromal symptoms and progressive pathology in mice. Transl Neurodegener. doi : 10.1186/s40035-019-0154-z.
Fragni M, Galli D, Nardini M, Rossini E, Vezzoli S, Zametta M, Longhena F, Bellucci A, Roca E, Memo M, Berruti A, Sigala S. Abiraterone Acetate Exerts a Cytotoxic Effect in Human Prostate Cancer Cell Lines. Naunyn Schmiedebergs Arch Pharmacol. doi: 10.1007/s00210-019-01622-5.
Bono F, Mutti V, Savoia P, Barbon A, Bellucci A, Missale C, Fiorentini C. Nicotine Prevents Alpha-Synuclein Accumulation in Mouse and Human iPSC-derived Dopaminergic Neurons Through Activation of the Dopamine D3- Acetylcholine Nicotinic Receptor Heteromer. Neurobiol dis. doi: 10.1016/j.nbd.2019.04.017.
Belleri M, Coltrini , Righi M , Ravelli C , Taranto S , Chiodelli P, Mitola S , Presta M and Giacomini A. β-Galactosylceramidase Deficiency Causes Bone Marrow Vascular Defects in an Animal Model of Krabbe Disease. Int J Mol Sci. doi: 10.3390/ijms21010251.
Faustini G., Marchesan E., Zonta L., Bono F., Bottani E., Longhena F., Ziviani E., Valerio E. and Bellucci A. Alpha-synuclein preserves mitochondrial Fusion and Function in Neuronal cells. Oxidative Medicine and cellular Longevity. DOI: 10.1155/2019/4246350.
2018
Faustini G, Longhena F, Varanita T, Bubacco L, Pizzi M, Missale C, Benfenati F, Björklund A, Spano P, Bellucci A. Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease. Acta Neuropathol. doi:10.1007/s00401-018-1892-1.
Monzio Compagnoni G, Kleiner G, Samarani M, Aureli M, Faustini G, Bellucci A, et al. Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy. Stem Cell Reports. doi: 10.1016/j.stemcr.2018.09.007.
Longhena F, Faustini G, Missale C, Pizzi M, Bellucci A. Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study. Int J Mol Sci. doi: 10.3390/ijms19061611.
Longhena F, Faustini G, Varanita T, Zaltieri M, Porrini V, Tessari I, Poliani PL, Missale C, Borroni B, Padovani A, Bubacco L, Pizzi M, Spano P, Bellucci A. Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains. Brain Pathol. doi: 10.1111/bpa.12587.
Salvadori A, Damioli V, Ravelli C, and Mitola S. Modeling and Simulation of VEGF Receptors Recruitment in angiogenesis. Mathematical Problems in Engineering. doi.org/10.1155/2018/4705472.
Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi RW, Gennarelli M, Piovani G, Kunath T, Millan MJ, Merlo Pich E, Spano P. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 10.1155/2018/4196961
2017
Bono F, Savoia P, Guglielmi A, Gennarelli M, Piovani G, Sigala S, Leo D, Espinoza S, Gainetdinov RR, Devoto P, Spano P, Missale C, Fiorentini C. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Mol Neurobiol. doi: 10.1007/s12035-016-0376-3.
Rezzola, S., Nawaz, I. M., Cancarini, A., Ravelli, C., Calza, S., Semeraro, F., & Presta, M. 3D endothelial cell spheroid/human vitreous humor assay for the characterization of anti-angiogenic inhibitors for the treatment of proliferative diabetic retinopathy. Angiogenesis. http://doi.org/10.1007/s10456-017-9575-4.
Longhena F, Zaltieri M, Grigoletto J, Faustini G, La Via L, Ghidoni R, Benussi L, Missale C, Spano P, Bellucci A. Depletion of progranulin reduces GluN2B-containing NMDA receptor density, tau phosphorylation, and dendritic arborization in mouse primary cortical neurons. Journal of Pharmacology and Experimental Therapeutics. doi:10.1124/jpet.117.242164.
Schlich M, Longhena F, Faustini G, O'Driscoll CM, Sinico C, Fadda AM, Bellucci A, Lai F. Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy. Nano Research. doi:10.1007/s12274-017-1561-z.