Call for proposal: Medical Research Conuncil
Role: Partner
Start date:
- End date:
Type of funding: International
Responsible of the project: Prof. Vito Romano
Department: Department of Medicine and Surgery, Radiology and Public Health
Abstract
The aim of this project is to develop a good manufacturing practice (GMP) aligned method to create poly-epsilon-lysine
based corneal endothelial grafts that are shown to be safe and effective in vivo.
Objectives:
Objective 1: Define the optimum formulation of the hydrogels to provide compatibility with human CECs and suitable thickness and integrity for transplantation.
Objective 2: Define the standard operating procedure for GMP aligned culture of human CECs on hydrogels.
Objective 3: Test the safety and efficacy of the grafts in vitro and in an in vivo rabbit model of corneal endothelial damage
Participants
University of Liverpool (Coordinator), UK
Università degli Studi di Brescia, Italy
Overall funding assigned to UniBS: € 48.500,00